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. 2019 Feb;15(5):485-494.
doi: 10.2217/fon-2018-0613. Epub 2019 Jan 9.

Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer

Gustavo T Silva  1 , Larissy M Silva  2 , Anke Bergmann  2 , Luiz Cs Thuler  2   3
Affiliations

Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer

Gustavo T Silva et al. Future Oncol. 2019 Feb.

Abstract

Aim: Estimate the incidence of bone metastases (BM) and skeletal-related events according to the histological subtype of lung cancer and its impact on patient survival.

Patients & methods: Retrospective cohort study was carried out with patients diagnosed with lung cancer. Cumulative incidence, Kaplan-Meier survival analysis and the risk of death were estimated.

Results: In non-small-cell lung cancer (NSCLC), the cumulative incidence of BM during follow-up was 23.8% at 24 months; in small-cell lung cancer, it was 18.5%. The presence of BM in patients with NSCLC was associated with an increased risk of death (hazard ratio: 1.25; 95% CI: 1.04-1.49; p = 0.013).

Conclusion: This study revealed a high incidence of BM and skeletal-related events. BM was associated with a poor prognosis in NSCLC patients.

Keywords: bone metastases; histological subtype; incidence; lung cancer; skeletal-related events.

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