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Review
. 2018 Dec;36(5-6):187-195.
doi: 10.1080/08977194.2018.1548444. Epub 2019 Jan 9.

Growth factor signalling in osteoarthritis

Jian Huang  1 , Lan Zhao  1 , Di Chen  1
Affiliations
Review

Growth factor signalling in osteoarthritis

Jian Huang et al. Growth Factors. 2018 Dec.

Abstract

Osteoarthritis (OA) is one of the most common diseases, affecting more than 10% of populations and thus creating immense socioeconomic burden. The pathological changes of OA involve the entire joint, which is composed of multiple types of tissues and cells, exemplified by cartilage degradation, subchondral bone thickening, osteophyte formation, synovium inflammation and hypertrophy, and ligament degeneration. As joint homeostasis requires a complex network of growth factors to regulate anabolic and catabolic events, the dysregulation of growth factor signalling would have negative impacts on structure and function of multiple joint tissues and eventually lead to the onset and progression of OA. In this review, we will discuss TGF-β, NGF, Hedgehog and Wnt, the four growth factors which have received extensive attention in the field of OA and clinical/translational interrogation about their application in OA therapies.

Keywords: Hedgehog; NGF; Osteoarthritis; TGF-β; Wnt.

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References

    1. Aloe L, Tuveri MA, Carcassi U, and Levi-Montalcini R. 1992. “Nerve growth factor in the synovial fluid of patients with chronic arthritis.” Arthritis Rheum 35 (3):351–5. - PubMed
    1. Bakker AC, van de Loo FAJ, van Beuningen HM, Sime P, van Lent PLEM, van der Kraan PM, Richards CD, and van den Berg WB. 2001. “Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation.” Osteoarthritis and Cartilage 9 (2):128–36. doi: 10.1053/joca.2000.0368. - DOI - PubMed
    1. Ballock R. Tracy, Heydemann Ahlke, Wakefield Lalage M., Flanders Kathleen C., Roberts Anita B., and Sporn Michael B.. 1993. “TGF-β1 Prevents Hypertrophy of Epiphyseal Chondrocytes: Regulation of Gene Expression for Cartilage Matrix Proteins and Metalloproteases.” Developmental Biology 158 (2):414–29. doi: 10.1006/dbio.1993.1200. - DOI - PubMed
    1. Blaney Davidson EN, Vitters EL, van der Kraan PM, and van den Berg WB. 2006. “Expression of transforming growth factor-β (TGF-β) and the TGF-β signalling molecule Smad2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation.” Annals of the Rheumatic Diseases 65 (11):1414–21. doi: 10.1136/ard.2005.045971. - DOI - PMC - PubMed
    1. Blaney Davidson EN, Vitters EL, Bennink MB, van Lent PL, van Caam AP, Blom AB, van den Berg WB, van de Loo FA, and van der Kraan PM. 2015. “Inducible chondrocyte-specific overexpression of BMP-2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.” Ann Rheum Dis 74 (6):1257–64. doi: 10.1136/annrheumdis-2013-204528. - DOI - PubMed

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