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. 2019 Jun;91(6):1142-1147.
doi: 10.1002/jmv.25397. Epub 2019 Jan 21.

Impact of HPyV9 and TSPyV coinfection on the development of BK polyomavirus viremia and associated nephropathy after kidney transplantation

Aline L van Rijn  1 , Herman F Wunderink  2 , Caroline S de Brouwer  1 , Els van der Meijden  1 , Joris I Rotmans  3 , Mariet C W Feltkamp  1
Affiliations

Impact of HPyV9 and TSPyV coinfection on the development of BK polyomavirus viremia and associated nephropathy after kidney transplantation

Aline L van Rijn et al. J Med Virol. 2019 Jun.

Abstract

Background: BK polyomavirus (BKPyV) persistently infects the urinary tract and causes viremia and nephropathy in kidney transplantation (KTx), recipients. In a previous study, we observed an increased incidence and load of BKPyV viremia in KTx patients coinfected with human polyomavirus 9 (HPyV9). Here we sought confirmation of this observation and explored whether novel HPyVs that have been detected in urine (HPyV9 and trichodysplasia spinulosa polyomavirus [TSPyV]) potentially aggravate BKPyV infection.

Methods: A well-characterized cohort of 209 KTx donor-recipient pairs was serologically and molecularly analyzed for HPyV9 and TSPyV coinfection. These data were correlated with the occurrence of BKPyV viremia and BKPyVAN in the recipients within a year after KTx.

Results: Seropositivity for HPyV9 (19%) and TSPyV (89%) was comparable between donors and recipients and did not correlate with BKPyV viremia and BKPyVAN that developed in 25% and 3% of the recipients, respectively. Two recipients developed TSPyV viremia and none HPyV9 viremia. Modification of the predictive effect of donor BKPyV seroreactivity on recipient BKPyV viremia by HPyV9 and TSPyV was not observed.

Conclusions: Our data provide no evidence for a promoting effect of HPyV9 and TSPyV on BKPyV infection and BKPyVAN in renal allograft patients. Therefore, we do not recommend including HPyV9 and TSPyV screening in KTx patients.

Keywords: BK infection; BK polyomavirus; BKPyV-associated nephropathy; human polyomavirus 9; kidney transplantation; trichodysplasia spinulosa polyomavirus.

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Figures

Figure 1
Figure 1
Pre‐KTx, HPyV9, and TSPyV seropositivity and seroreactivity of donors and recipients. HPyV9, human polyomavirus 9; KTx, kidney transplantation; MFI, median fluorescence intensity; TSPyV, trichodysplasia spinulosa polyomavirus
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