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Comment
. 2019 Jan 8;29(1):3-4.
doi: 10.1016/j.cmet.2018.12.012.

NASH and HCC Are Driven by Different Signaling Pathways with a Common Regulator

Wajahat Mehal  1
Affiliations
Free article
Comment

NASH and HCC Are Driven by Different Signaling Pathways with a Common Regulator

Wajahat Mehal. Cell Metab. .
Free article

Abstract

Oxidative stress is uniformly present in non-alcoholic steatohepatitis (NASH), but its role in the development of liver inflammation and hepatocellular cancer (HCC) and the relationship between these two pathologies are poorly understood. In a recent issue of Cell, Grohmann et al. (2018) demonstrate a vital role of obesity-induced oxidative stress in deactivating the phosphatase TCPTP, resulting in activation of STAT-1 and STAT-3, which each independently drive the development of NASH and HCC, respectively.

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  • Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.
    Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, Treloar AE, Archer S, Brown WA, Muller M, Watt MJ, Ohara O, McLean CA, Tiganis T. Grohmann M, et al. Cell. 2018 Nov 15;175(5):1289-1306.e20. doi: 10.1016/j.cell.2018.09.053. Epub 2018 Oct 25. Cell. 2018. PMID: 30454647 Free PMC article.

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