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Comment
. 2019 Jan 8;29(1):9-10.
doi: 10.1016/j.cmet.2018.12.009.

Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease

Janina Müller-Deile  1 , Tilman Jobst-Schwan  1 , Mario Schiffer  2
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Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease

Janina Müller-Deile et al. Cell Metab. .
Free article

Abstract

Genome-wide association studies (GWAS) have identified multiple chronic kidney disease (CKD)-associated single-nucleotide polymorphisms (SNPs) mainly localized to non-coding genomic regions. To understand which genes and which cell types are affected by these genetic variants, compartment-specific transcriptome, genome, and epigenome data were analyzed in an integrative manner in a recent study by Qiu et al. (Qiu et al., 2018).

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