Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 8;6(1):5.
doi: 10.3390/children6010005.

Non-High-Risk Neuroblastoma: Classification and Achievements in Therapy

Holly J Meany  1
Affiliations

Non-High-Risk Neuroblastoma: Classification and Achievements in Therapy

Holly J Meany. Children (Basel). .

Abstract

Neuroblastoma, a tumor of the sympathetic nervous system, is the most common extra-cranial neoplasm of childhood. Variables with prognostic significance in patients with neuroblastoma, including age at diagnosis, disease stage, tumor histology, MYCN gene amplification, tumor cell ploidy, and the presence of segmental chromosomal aberrations are utilized to classify patients based on risk of disease recurrence. Patients with non-high-risk neuroblastoma, low- and intermediate-risk categories, represent nearly half of all newly diagnosed cases. This group has an excellent event-free and overall survival with current therapy. Over time, the objective in treatment of non-high-risk neuroblastoma has been reduction of therapy intensity to minimize short- and long-term adverse events all the while maintaining excellent outcomes.

Keywords: classification; intermediate risk neuroblastoma; low-risk neuroblastoma; neuroblastoma; treatment.

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

References

    1. Howlader N., Noone A.M., Krapcho M., Neyman N., Aminou R., Waldron W., Altekruse S.F., Kosary C.L., Ruhl J., Tatalovich Z., et al. SEER Cancer Statistics Review, 1975–2009 (Vintage 2009 Populations) National Cancer Institute; Bethesda, MD, USA:
    1. Cotterill S.J., Pearson A.D., Pritchard J., Foot A.B., Roald B., Kohler J.A. Clinical prognostic factors in 1277 patients with neuroblastoma: Results of The European Neuroblastoma Study Group ‘Survey’ 1982–1992. Eur. J. Cancer. 2000;36:901–908. doi: 10.1016/S0959-8049(00)00058-7. - DOI - PubMed
    1. London W.B., Boni L., Simon T., Berthold F., Twist C., Schmidt M.L., Castleberry R.P., Matthay K.K., Cohn S.L., De Bernardi B. The role of age in neuroblastoma risk stratification: The German, Italian, and children’s oncology group perspectives. Cancer Lett. 2005;228:257–266. doi: 10.1016/j.canlet.2004.12.054. - DOI - PubMed
    1. London W.B., Castleberry R.P., Matthay K.K., Look A.T., Seeger R.C., Shimada H., Thorner P., Brodeur G., Maris J.M., Reynolds C.P., et al. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children’s Oncology Group. J. Clin. Oncol. 2005;23:6459–6465. doi: 10.1200/JCO.2005.05.571. - DOI - PubMed
    1. Cohn S.L., Pearson A.D., London W.B., Monclair T., Ambros P.F., Brodeur G.M., Faldum A., Hero B., Iehara T., Machin D., et al. INRG Task Force. The International Neuroblastoma Risk Group (INRG) classification system: An INRG Task Force report. J. Clin. Oncol. 2009;27:289–297. doi: 10.1200/JCO.2008.16.6785. - DOI - PMC - PubMed

LinkOut - more resources