The Pearson's correlation coefficient is not a universally superior colocalization metric. Response to 'Quantifying colocalization: the MOC is a hybrid coefficient - an uninformative mix of co-occurrence and correlation'

Affiliations

¹ Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147, USA.
² Biomedical Research Core Facilities, University of Michigan Medical School, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-0674, USA.
³ Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147, USA chewt@janelia.hhmi.org.

Comment

Jesse S Aaron et al. J Cell Sci. 2019.

. 2019 Jan 9;132(1):jcs227074.

doi: 10.1242/jcs.227074.

¹ Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147, USA.
² Biomedical Research Core Facilities, University of Michigan Medical School, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-0674, USA.
³ Advanced Imaging Center, Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147, USA chewt@janelia.hhmi.org.

No abstract available

Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

Image co-localization - co-occurrence versus correlation.
Aaron JS, Taylor AB, Chew TL. Aaron JS, et al. J Cell Sci. 2018 Feb 8;131(3):jcs211847. doi: 10.1242/jcs.211847. J Cell Sci. 2018. PMID: 29439158 Review.
Quantifying colocalization: the MOC is a hybrid coefficient - an uninformative mix of co-occurrence and correlation.
Adler J, Parmryd I. Adler J, et al. J Cell Sci. 2019 Jan 9;132(1):jcs222455. doi: 10.1242/jcs.222455. J Cell Sci. 2019. PMID: 30626689 No abstract available.