Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Oct 10:2018:5406973.
doi: 10.1155/2018/5406973. eCollection 2018.

Do MicroRNAs Modulate Visceral Pain?

Zhuo-Ying Tao  1   2 , Yang Xue  1 , Jin-Feng Li  2 , Richard J Traub  3 , Dong-Yuan Cao  1
Affiliations
Review

Do MicroRNAs Modulate Visceral Pain?

Zhuo-Ying Tao et al. Biomed Res Int. .

Abstract

Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The classic pathway of miRNA biogenesis.
See this image and copyright information in PMC

References

    1. Portela A., Esteller M. Epigenetic modifications and human disease. Nature Biotechnology. 2010;28(10):1057–1068. doi: 10.1038/nbt.1685. - DOI - PubMed
    1. Varela M. A., Roberts T. C., Wood M. J. A. Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy. Neurotherapeutics. 2013;10(4):621–631. doi: 10.1007/s13311-013-0212-7. - DOI - PMC - PubMed
    1. Gräff J., Kim D., Dobbin M. M., Li-Huei T. Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes. Physiological Reviews. 2011;91(2):603–649. doi: 10.1152/physrev.00012.2010. - DOI - PubMed
    1. Calin G. A., Dumitru C. D., Shimizu M. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America; pp. 15524–15529. - PMC - PubMed
    1. van Rooij E., Sutherland L. B., Liu N. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proceedings of the National Acadamy of Sciences of the United States of America. 2006;103(48):18255–18260. doi: 10.1073/pnas.0608791103. - DOI - PMC - PubMed

MeSH terms