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Comment
. 2019 Jan 9;25(1):1-2.
doi: 10.1016/j.chom.2018.12.009.

Crossing the Mucosal Barrier: A Commensal Bacterium Gives Dengue Virus a Leg-Up in the Mosquito Midgut

Pascal Miesen  1 , Ronald P van Rij  2
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Crossing the Mucosal Barrier: A Commensal Bacterium Gives Dengue Virus a Leg-Up in the Mosquito Midgut

Pascal Miesen et al. Cell Host Microbe. .
Free article

Abstract

Commensal bacteria that colonize the midgut of Aedes aegypti mosquitoes can influence the transmission of arthropod-borne viruses. In this issue of Cell Host & Microbe, Wu et al. (2019) show that Serratia marcescens bacteria secrete enhancin proteins that cleave membrane-bound mucins, thereby facilitating dengue virus infection of midgut epithelial cells.

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