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. 2018 Dec;36(4):254-264.
doi: 10.3857/roj.2018.00500. Epub 2018 Dec 31.

Management for locally advanced cervical cancer: new trends and controversial issues

Oyeon Cho  1 , Mison Chun  1
Affiliations

Management for locally advanced cervical cancer: new trends and controversial issues

Oyeon Cho et al. Radiat Oncol J. 2018 Dec.

Abstract

This article reviewed new trends and controversial issues, including the intensification of chemotherapy and recent brachytherapy (BT) advances, and also reviewed recent consensuses from different societies on the management of locally advanced cervical cancer (LACC). Intensive chemotherapy during and after radiation therapy (RT) was not recommended as a standard treatment due to severe toxicities reported by several studies. The use of positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) for pelvic RT planning has increased the clinical utilization of intensity-modulated radiation therapy (IMRT) for the evaluation of pelvic lymph node metastasis and pelvic bone marrow. Recent RT techniques for LACC patients mainly aim to minimize toxicities by sparing the normal bladder and rectum tissues and shortening the overall treatment time by administering a simultaneous integrated boost for metastatic pelvic lymph node in pelvic IMRT followed by MRI-based image guided adaptive BT.

Keywords: Brachytherapy; Drug therapy; Intensity-modulated radiotherapy; Uterine cervical neoplasms.

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Conflict of interest statement

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

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