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Comment
. 2019 Apr 1;25(7):2024-2026.
doi: 10.1158/1078-0432.CCR-18-3724. Epub 2019 Jan 10.

Mapping Physical Tumor Microenvironment and Drug Delivery

Hadi T Nia  1 , Lance L Munn  1 , Rakesh K Jain  2
Affiliations
Comment

Mapping Physical Tumor Microenvironment and Drug Delivery

Hadi T Nia et al. Clin Cancer Res. .

Abstract

The physical microenvironment of pancreatic tumors is highly abnormal, and this causes significant challenges for drug delivery through multiple mechanisms. Measurements of tissue elasticity could be used as a physical biomarker to assess aberrant drug delivery, and potentially guide stroma-targeting treatment strategies and patient stratification.See related article by Wang et al., p. 2136.

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Conflict of interest statement

Conflict of interest: RKJ received honorarium from AMGEN, consultant fees from Pfizer, Ophthotech, Merck, SPARC, SynDevRx and XTuit. RKJ owns equity in Enlight, Ophthotech and SynDevRx, and serves on the Board of Directors of XTuit and the Boards of Trustees of Tekla Healthcare Investors, Tekla Life Sciences Investors, the Tekla Healthcare Opportunities Fund and the Tekla World Healthcare Fund. LLM receives equity from Bayer Pharmaceuticals. No funding or reagents from these organizations were used in this work.

Figures

Figure 1
Figure 1. Drug delivery in tumors are affected by physical microenvironment.
Elevated fluid pressure, solid stress and stiffness, the three main features of physical microenvironment in most tumors with distinct origins and consequences affect drug delivery through different mechanisms.
See this image and copyright information in PMC

Comment on

References

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    1. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 2016;1:0004. - PMC - PubMed
    1. Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, et al. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nature Communications. 2013;4. - PMC - PubMed

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