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Comment
. 2019 Aug;21(8):1878-1879.
doi: 10.1038/s41436-018-0401-1. Epub 2018 Dec 14.

Are women with pathogenic variants in PMS2 and MSH6 really at high lifetime risk of breast cancer?

D G Evans  1   2 , E R Woodward  3   4 , F Lalloo  3 , P Møller  5 , J Sampson  6 , J Burn  7 , G Moeslein  8 , G Capella  9
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Free article
Comment

Are women with pathogenic variants in PMS2 and MSH6 really at high lifetime risk of breast cancer?

D G Evans et al. Genet Med. 2019 Aug.
Free article
No abstract available

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Comment in

  • Response to Evans et al.
    Roberts ME, Zeinomar N, Solomon BD, Terry MB, Chung WK. Roberts ME, et al. Genet Med. 2019 Aug;21(8):1880-1881. doi: 10.1038/s41436-018-0400-2. Epub 2018 Dec 19. Genet Med. 2019. PMID: 30563985 No abstract available.

Comment on

References

    1. Roberts ME, Jackson SA, Susswein LR, et al. MSH6 and PMS2 germ-line pathogenic variants implicated in Lynch syndrome are associated with breast cancer. Genet Med. 2018;20:1167–1174. - DOI
    1. Møller P, Seppälä TT, Bernstein I, et al. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut. 2018;67:1306–1316. - DOI
    1. Susswein LR, Marshall ML, Nussbaum R, et al. Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. Genet Med. 2016;18:823–832. - DOI
    1. Ten Broeke SW, van der Klift HM, Tops CMJ, et al. Cancer risks for PMS2-associated Lynch syndrome. J Clin Oncol. 2018;36:2961–2968. - DOI
    1. Couch FJ, Shimelis H, Hu C, et al. Associations between cancer predisposition testing panel genes and breast cancer. JAMA Oncol. 2017;3:1190–1196. - DOI

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