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Review
. 2018 Dec 7:7:F1000 Faculty Rev-1909.
doi: 10.12688/f1000research.16222.1. eCollection 2018.

Recent advances in understanding chronic rhinosinusitis endotypes

Eric F Succar  1 , Justin H Turner  1
Affiliations
Review

Recent advances in understanding chronic rhinosinusitis endotypes

Eric F Succar et al. F1000Res. .

Abstract

Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with an as-yet-undefined etiology. The management of CRS has historically been phenotypically driven, and the presence or absence of nasal polyps has frequently guided diagnosis, prognosis, and treatment algorithms. Research over the last decade has begun to question the role of this distinction in disease management, and renewed attention has been placed on molecular and cellular endotyping and a more personalized approach to care. Current research exploring immunologic mechanisms, inflammatory endotypes, and molecular biomarkers has the potential to more effectively delineate distinct and clinically relevant subgroups of CRS. The focus of this review will be to discuss and summarize the endotypic characterization of CRS and the potential diagnostic and therapeutic implications of this approach to disease management.

Keywords: T-helper cell; cluster; cytokine; endotype; nasal polyps; phenotype.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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