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Review
. 2018 Dec 2:2018:4601420.
doi: 10.1155/2018/4601420. eCollection 2018.

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development

Micaella Kantor  1 , Anarella Abrantes  1 , Andrea Estevez  1 , Alan Schiller  1 , Jose Torrent  1 , Jose Gascon  1 , Robert Hernandez  1 , Christopher Ochner  2
Affiliations
Review

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development

Micaella Kantor et al. Can J Gastroenterol Hepatol. .

Abstract

Entamoeba histolytica is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with E. histolytica remain asymptomatic, some present with amoebic colitis and disseminated disease. As more is learned about its pathogenesis and the host's immune response, the potential for developing a vaccine holds promise. This narrative review outlines the current knowledge regarding E. histolytica and E. dispar and insight in the development of a vaccine.

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