Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec 2:2018:9162921.
doi: 10.1155/2018/9162921. eCollection 2018.

Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Not Clinically Useful in Predicting Prognosis in Early Stage Cervical Cancer

Prachratana Nuchpramool  1 , Jitti Hanprasertpong  1
Affiliations

Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Not Clinically Useful in Predicting Prognosis in Early Stage Cervical Cancer

Prachratana Nuchpramool et al. Surg Res Pract. .

Abstract

Background: An objective of this study was to determine the prognostic role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with cervical cancer (CC) stages IA2-IB1.

Methods: The study included 484 patients who underwent radical hysterectomy with pelvic node dissection. The associations of preoperative NLR and PLR with clinicopathologic characteristics and oncological outcomes were analyzed. The cut-off values of NLR (=1.8) and PLR (=119) were set as medians.

Results: The clinicopathologic analysis showed that NLR was associated with age (p=0.010), tumor size (p=0.045), and adjuvant treatment (p=0.005), and PLR was associated with only adjuvant treatment (p=0.033). DFS and OS were not significantly different between patients with high and low NLR (p=0.670 and p=0.934) or high and low PLR (p=0.780 and p=0.306). The independent prognostic factors associated with OS were lymph node status and anemia, and with DFS were histology, deep stromal invasion, and lymph node status.

Conclusions: NLR and PLR have no use as prognostic biomarker for DFS and OS in early-stage CC. However, NLR and PLR might be of use in determining the risk for adjuvant treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The disease-free survival according to neutrophil/lymphocyte ratio (a) and platelet/lymphocyte ratio (b).
Figure 2
Figure 2
The overall survival according to neutrophil/lymphocyte ratio (a) and platelet/lymphocyte ratio (b).
See this image and copyright information in PMC

References

    1. Hanprasertpong J., Jiamset I., Geater A., Peerawong T., Hemman W., Kornsilp S. The effect of metformin on oncological outcomes in cervical cancer patients with type 2 diabetes mellitus. International Journal of Gynecological Cancer. 2017;27(1):131–137. doi: 10.1097/igc.0000000000000855. - DOI - PubMed
    1. Chittithaworn S., Hanprasertpong J., Tungsinmunkong K., Geater A. Association between prognostic factors and disease-free survival of cervical cancer stage Ib1 patients undergoing radical hysterectomy. Asian Pacific Journal of Cancer Prevention. 2007;8:530–534. - PubMed
    1. Jiamset I., Hanprasertpong J. Risk factors to determine parametrial involvement in early stage cervical cancer and identification of patients suitable for less radical surgery. Oncology Research and Treatment. 2016;39(7-8):432–438. doi: 10.1159/000447335. - DOI - PubMed
    1. Chandeying N., Hanprasertpong J. The prognostic impact of histological type on clinical outcomes of early-stage cervical cancer patients whom have been treated with radical surgery. Journal of Obstetrics and Gynaecology. 2017;37(3):347–354. doi: 10.1080/01443615.2016.1245279. - DOI - PubMed
    1. Van Nagell J. R., Jr., Roddick J. W., Jr., Lowin D. M. The staging of cervical cancer: inevitable discrepancies between clinical staging and pathologic findinges. American Journal of Obstetrics and Gynecology. 1971;110(7):973–978. doi: 10.1016/0002-9378(71)90551-5. - DOI - PubMed

LinkOut - more resources