Could genetic and epigenetic factors explain hypoxia tolerance and superior muscle performance of Sherpas at high-altitude?
- PMID: 30632151
- PMCID: PMC6395412
- DOI: 10.1113/JP277593
Could genetic and epigenetic factors explain hypoxia tolerance and superior muscle performance of Sherpas at high-altitude?
Keywords: Epigenetics; Genetics; High altitude; Muscle fatigue.
Comment on
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Catecholamine response to exercise in patients with non-obstructive hypertrophic cardiomyopathy.J Physiol. 2019 Mar;597(5):1337-1346. doi: 10.1113/JP277494. Epub 2019 Jan 9. J Physiol. 2019. PMID: 30552684 Free PMC article.
References
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- Gilbert‐Kawai ET, Milledge JS, Grocott MP & Martin DS (2014). King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude. Physiology (Bethesda) 29, 388–402. - PubMed
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- Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert‐Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS & Murray AJ (2017). Metabolic basis to Sherpa altitude adaptation. Proc Natl Acad Sci U S A 114, 6382–6387. - PMC - PubMed
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