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. 2019 Apr;14(4):588-590.
doi: 10.4103/1673-5374.247460.

Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation

Xu-Qiao Chen  1
Affiliations

Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation

Xu-Qiao Chen. Neural Regen Res. 2019 Apr.
No abstract available

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
T-complex protein 1-ring complex (TRiC)/chaperonin containing T-complex protein 1 (CCT) subunit enhances retrograde axonal transport by modulating tau phosphorylation. CCT enhances retrograde axonal transport of brain-derived neurotrophic factor (BDNF) in primary cortical neurons. The net effect on retrograde axonal transport of BDNF by CCT is the reduction in pauses with a concomitant increase in transport velocities. Importantly, the effect of CCT subunit on retrograde axonal transport of BDNF required tau expression. Mechanically, upregulation of CCT subunit increases the level of cyclin-dependent kinase 5 (CDK5)/p35/p25 in a tau-dependent manner, resulting in tau phosphorylation, which potentially induced tau detachment from microtubules.
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References

    1. Brehme M, Voisine C, Rolland T, Wachi S, Soper JH, Zhu Y, Orton K, Villella A, Garza D, Vidal M, Ge H, Morimoto RI. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep. 2014;9:1135–1150. - PMC - PubMed
    1. Chen XQ, Sawa M, Mobley WC. Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free Radic Biol Med. 2018a;114:52–61. - PMC - PubMed
    1. Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018b;19:840–853. - PMC - PubMed
    1. Gratuze M, Cisbani G, Cicchetti F, Planel E. Is Huntington’s disease a tauopathy. Brain. 2016;139:1014–1025. - PubMed
    1. Khabirova E, Moloney A, Marciniak SJ, Williams J, Lomas DA, Oliver SG, Favrin G, Sattelle DB, Crowther DC. The TRiC/CCT chaperone is implicated in Alzheimer’s disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans. PLoS One. 2014;9:e102985. - PMC - PubMed