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. 2019 Apr;14(4):588-590.
doi: 10.4103/1673-5374.247460.

Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation

Xu-Qiao Chen  1
Affiliations

Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation

Xu-Qiao Chen. Neural Regen Res. 2019 Apr.
No abstract available

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
T-complex protein 1-ring complex (TRiC)/chaperonin containing T-complex protein 1 (CCT) subunit enhances retrograde axonal transport by modulating tau phosphorylation. CCT enhances retrograde axonal transport of brain-derived neurotrophic factor (BDNF) in primary cortical neurons. The net effect on retrograde axonal transport of BDNF by CCT is the reduction in pauses with a concomitant increase in transport velocities. Importantly, the effect of CCT subunit on retrograde axonal transport of BDNF required tau expression. Mechanically, upregulation of CCT subunit increases the level of cyclin-dependent kinase 5 (CDK5)/p35/p25 in a tau-dependent manner, resulting in tau phosphorylation, which potentially induced tau detachment from microtubules.
See this image and copyright information in PMC

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