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Published Erratum
. 2019 Feb;156(2):213.
doi: 10.1111/imm.13014. Epub 2018 Nov 26.

Corrigendum

No authors listed
Published Erratum

Corrigendum

No authors listed. Immunology. 2019 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Illustrative scheme of naive T cell differentiation into T helper type 1 (Th1), Th2, Th17 or regulatory T (Treg) cells, depending on the cytokine profile. Interleukin‐12 (IL‐12) and interferon‐γ (IFN‐γ) stimulated naive T cells differentiate to Th1 cells. These cells express IFN‐γ and tumour necrosis factor‐a (TNF‐α), and are responsible for intracellular parasite clearance. IL‐4 stimulated naive T cells induce a Th2 response. Th2 cells express IL‐4, IL‐5 and IL‐13, and are responsible for clearance of extracellular parasites. Transforming growth factor‐β (TGF‐β) stimulated naive T cells induce a Treg response. Treg cells express TGF‐β and IL‐10 and are responsible for tolerance and pregnancy success. These three cell types express one cytokine responsible for its induction, in a positive feedback mechanism. TGF‐β and IL‐6 stimulated naive T cells induce a Th17 response. Th17 cells express IL‐17, IL‐21 and IL‐22 and are responsible for autoimmunity and pregnancy loss. Th17 cells do not present a positive feedback mechanism, but IFN‐γ or IL‐4 can inhibit the differentiation from naive T cells to Th17. Moreover, IL‐6 and IL‐12 inhibit Treg and Th2 cells, respectively.
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Erratum for

References

    1. Figueiredo AS, Schumacher A. The T helper type 17/regulatory T cell paradigm in pregnancy. Immunology 2016; 148:13–21. - PMC - PubMed

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