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Meta-Analysis
. 2019 Jan;98(2):e13813.
doi: 10.1097/MD.0000000000013813.

Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis

Jiang Yuepeng  1 , Xiaoxuan Zhao  1 , Yang Zhao  2 , Liu Li  3
Affiliations
Meta-Analysis

Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease: A meta-analysis

Jiang Yuepeng et al. Medicine (Baltimore). 2019 Jan.

Abstract

To evaluate the association between gene polymorphisms of TNF-α G308A, IL-6 C174G, and coronary atherosclerotic heart disease (CHD) risk.We used computers to collect related case-control studies. After screening, a meta-analysis was conducted to assess the strength of association by Stata 12.0 software.Thirty-five articles were included. Among them, 17 studies were related to TNF-α (G308A) gene mutation and CHD, and 18 studies examined IL-6 (C174G) gene mutation. According to the results of subgroup analysis of ethnicity, it suggested that TNF-α (G308A) polymorphism was not significantly associated with CHD risk under all models in Asians (P > .05). There were no connected of IL-6 C174G polymorphism with CHD risk under all models in Caucasians after subgroup analysis (P > .05).The present evidence shows that TNF-α (G308A) have no connected with the risk of CHD in Asians; IL-6 (C174G) gene were not associated with the risk of CHD in Caucasians.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there are no conflicts of interest. And manuscript is approved by all authors for publication.

Figures

Figure 1
Figure 1
Article screening flowchart.
Figure 2
Figure 2
Forest plot of IL-6 C174G polymorphism and CHD risk. CHD = coronary atherosclerotic heart disease, IL-6 = interleukin-6.
Figure 3
Figure 3
Sensitivity analyses for IL-6 C174G CG versus GG polymorphism and CHD. CHD = coronary atherosclerotic heart disease, IL-6 = interleukin-6.
Figure 4
Figure 4
The publication bias of articles on the relationship between TNF-α G308A and CHD risk was shown in the funnel figure. CHD = coronary atherosclerotic heart disease, TNF-α = tumor necrosis factor-alpha.
Figure 5
Figure 5
The publication bias of articles on the relationship between IL-6 C174G and CHD risk was shown in the funnel figure. CHD = coronary atherosclerotic heart disease, IL-6 = interleukin-6.
See this image and copyright information in PMC

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