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Comment
. 2019 May 1;199(9):1171-1172.
doi: 10.1164/rccm.201812-2249LE.

Reply to Polverino: Deconvoluting Chronic Obstructive Pulmonary Disease: Are B Cells the Frontrunners?

Maha Zohra Ladjemi  1   2 , Pierre Régis Burgel  3   4 , Charles Pilette  1   2   5
Affiliations
Comment

Reply to Polverino: Deconvoluting Chronic Obstructive Pulmonary Disease: Are B Cells the Frontrunners?

Maha Zohra Ladjemi et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Microbial and (modified) self-antigens may trigger the generation of peribronchial lymphoid follicles where adaptive production of IgA antibodies takes place, probably upon activation by BAFF (B cell–activating factor), APRIL (a proliferation-inducing ligand), IL-6, and IL-21. After downregulation of the transport receptor pIgR (polymeric immunoglobulin receptor) in chronic obstructive pulmonary disease airway epithelium, immune exclusion mediated by secretory IgA is impaired, whereas subepithelial accumulation of (dimeric) IgA could trigger immune activation of myeloid cells and neutrophils expressing Fc RI (CD89).
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References

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