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Case Reports
. 2018 Dec 1;21(12):611-612.

Extramedullary Manifestation of Multiple Myeloma in the Oral Cavity

Cristiano de Assis Pereira Hansen  1 , Jayr Schmidt Filho  2 , Marina de Mattos Nascimento  2 , Fábio Abreu Alves  3 , Tatiane Neotti  4 , Felipe D Almeida Costa  5
Affiliations
  • PMID: 30634861
Case Reports

Extramedullary Manifestation of Multiple Myeloma in the Oral Cavity

Cristiano de Assis Pereira Hansen et al. Arch Iran Med. .

Abstract

Extramedullary plasmacytomas occurs in about 20% of multiple myeloma (MM) recurrences. Extramedullary disease seems to respond poorly to thalidomide and has adverse prognostic implication. When disease recurs in the oral cavity with soft tissue infiltration, some authors defend upfront surgical excision prior to radiotherapy with the aim of achieving better local control. We describe herein such an atypical case of recurrence from MM, with complete local response after 2 cycles of chemotherapy. Unfortunately, disease progressed later on, and the patient died after 9 months post-recurrence. This emphasizes the prognostic impact of extramedullary disease manifestation in MM.

Keywords: Multiple myeloma; Oral cavity; Recurrences.

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