Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 12;14(1):2.
doi: 10.1186/s13000-019-0782-8.

Histological characteristics of the largest and secondary tumors in radical prostatectomy specimens and implications for focal therapy

Young Hyo Choi  1 , Ji Woong Yu  1 , Byong Chang Jeong  1 , Seong Il Seo  1 , Seong Soo Jeon  1 , Hyun Moo Lee  1 , Hwang Gyun Jeon  2
Affiliations

Histological characteristics of the largest and secondary tumors in radical prostatectomy specimens and implications for focal therapy

Young Hyo Choi et al. Diagn Pathol. .

Abstract

Background: Pathological features of prostate cancer in Korean men were analyzed to determine whether identification of tumor volume, Gleason score (GS), focality, and location using radical prostatectomy (RP) specimens can provide useful information for the application of focal therapy (hemiablation).

Methods: From January 2016 to December 2017, 913 patients who underwent RP at a single center were selected for analysis. Patients with prostate-specific antigen levels > 15 ng/mL or those who had received hormone therapy prior to surgery were excluded. Preoperative data and the number, volume, location, and GS of each tumor were recorded.

Results: Overall, 762 RP specimens were examined, and 1448 tumors were identified. The majority of the cases were multifocal (60.5%) and bilateral (82%) in nature. Among the 686 secondary tumors, 250 (36.4%) had a GS ≥7 and 122 (17.8%) had a tumor volume ≥ 0.5 mL. Among the 435 bilateral multifocal cases, secondary tumors on the lobes contralateral to the largest tumor were significant by volume (≥0.5 mL) in 91 (20.9%) cases and by grade (GS ≥7) in 179 (41.1%) cases. There were 102 (23.4%) tumors with a small tumor volume (< 0.5 mL) and Gleason pattern 4 on the lobe contralateral to the largest tumor.

Conclusions: Bilateral and multifocal tumors are a common feature and secondary tumors frequently exhibit clinically significant prostate cancer on RP specimens in Korea. In many cases, secondary tumors on the lobe contralateral to the largest tumor had a high GS and small tumor volume.

Keywords: Focal therapy; Hemiablation; Histological characteristics; Prostate cancer; Radical prostatectomy specimen.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Our Institutional Review Board (IRB) approved this retrospective study and waived the requirement for informed consent (IRB no. 2018–04-082).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Distribution of 762 patients according to the number of tumors within the prostate gland
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. van der Poel HG, van den Bergh RCN, Briers E, Cornford P, Govorov A, Henry AM, Lam TB, Mason MD, Rouviere O, De Santis M, Willemse PM, van Poppel H, Mottet N. Focal therapy in primary localised prostate cancer: the European Association of Urology position in 2018. Eur Urol. 2018;74(1):84–91. - PubMed
    1. Valerio M, Ahmed HU, Emberton M, Lawrentschuk N, Lazzeri M, Montironi R, Nguyen PL, Trachtenberg J, Polascik TJ. The role of focal therapy in the management of localised prostate cancer: a systematic review. Eur Urol. 2014;66:732–751. doi: 10.1016/j.eururo.2013.05.048. - DOI - PMC - PubMed
    1. Valerio M, Cerantola Y, Eggener SE, Lepor H, Polascik TJ, Villers A, Emberton M. New and established Technology in Focal Ablation of the prostate: a systematic review. Eur Urol. 2017;71:17–34. doi: 10.1016/j.eururo.2016.08.044. - DOI - PubMed
    1. Giannarini G, Gandaglia G, Montorsi F, Briganti A. Will focal therapy remain only an attractive illusion for the primary treatment of prostate cancer? J Clin Oncol. 2014;32:1299–1301. doi: 10.1200/JCO.2013.54.8214. - DOI - PubMed
    1. Valerio M, Emberton M, Ahmed HU. Focal therapy will become a standard option for selected men with localized prostate cancer. J Clin Oncol. 2014;32:3680–3681. doi: 10.1200/JCO.2014.56.7792. - DOI - PubMed

Substances