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Randomized Controlled Trial
. 2018 Sep-Oct;50(5):236-241.
doi: 10.4103/ijp.IJP_250_18.

Efficacy of melatonin on sleep quality after laparoscopic cholecystectomy

Vaibhav Vij  1 , Divya Dahiya  1 , Lileswar Kaman  1 , Arunanshu Behera  1
Affiliations
Randomized Controlled Trial

Efficacy of melatonin on sleep quality after laparoscopic cholecystectomy

Vaibhav Vij et al. Indian J Pharmacol. 2018 Sep-Oct.

Abstract

Context: Postoperative sleep and circadian rhythm disturbances were associated with prolonged postoperative convalescence, respiratory, and cardiovascular morbidity. Sleep disturbances have been shown to be due to decreased levels of circulating melatonin after surgery. If this sleep pattern and circadian rhythm are recycled, outcome after surgery could be improved.

Aims: The aim of this study was to observe the effect of melatonin on the quality of sleep in patients undergoing laparoscopic cholecystectomy (LC).

Subjects and methods: Hundred patients of LC participated in this randomized, placebo-controlled, double-blind, clinical trial. Patients were randomized equally into Group A who received 6 mg melatonin tablets 45 min before sleep for 3 days after surgery and Group B who received placebo.

Results: Melatonin usage results in decrease in sleep latency (SL) as compared to placebo (13.6 ± 14.95 vs. 20.10 ± 16.18 min, P = 0.04). There was also increased total sleep duration (TSD) on postoperative day (POD) 1 (P = 0.004) and POD 2 (P = 0.001) in Group A. There was a decrease in daytime naps and night awakenings after surgery in Group A though it was not significant statistically. Subjective assessment of sleep on visual analog scale showed reduced sleep scores (P = 0.001 on POD 1 and 2) and decreased pain (P = 0.02 on POD 1) in Group A. Statistically significant difference was not observed in fatigue or general well-being among groups.

Conclusions: Results in this study could demonstrate that melatonin as a single agent could improve the quality of sleep after LC by decreasing SL and increasing TSD.

Keywords: Melatonin; laparoscopic cholecystectomy; sleep quality.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Sleep latency
Figure 2
Figure 2
Total sleep duration
See this image and copyright information in PMC

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