Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Summer;13(3):325-332.
Epub 2018 Sep 12.

Association of Helicobacter pylori Infection With Colon Cancer and Adenomatous Polyps

Fatemeh Teimoorian  1 , Mohammad Ranaei  2 , Karimollah Hajian Tilaki  3 , Javad Shokri Shirvani  4 , Zeinab Vosough  1
Affiliations

Association of Helicobacter pylori Infection With Colon Cancer and Adenomatous Polyps

Fatemeh Teimoorian et al. Iran J Pathol. 2018 Summer.

Abstract

Background and objective: Helicobacter pylori infection is one of the most common chronic bacterial infections in the world, especially in the developing countries. This bacterium is the cause of many diseases such as lymphoma, gastritis, peptic ulcers, and stomach cancer. According to recent reports, H. pylori infection can potentially increase the risk of colon cancer. The current study aimed at investigating the association of H. pylori infection and the risk of colorectal cancer and adenomatous polyps.

Methods: The current study was conducted on 50 patients with colon cancer and adenomatous polyps as the case group and 100 subjects with no specific pathologies (i e, polyps, neoplasms, or inflammatory diseases) as the control group. Blood samples were collected from the patients in order to assess the presence of anti-Helicobacter pylori infection antibodies, and the serum titer levels of anti-Helicobacter pylori IgG and IgA antibodies were measured using indirect enzyme-linked immunosorbent assay (ELISA) and a kit procured by Pishtaz Teb Company (Iran).

Results: A total of 33 patients in the current study had adenomatous polyps and 17 had colon cancer. H. pylori infection (IgA >20 U/mL and IgG >10 U/mL) was significantly more prevalent in the patients with colon cancer and adenomatous polyps compared with the healthy controls (P= 0.003, P= 0.039, respectively).

Conclusion: The obtained results suggested that H. pylori infection can be considered as a risk factor for colon cancer and adenomatous polyps.

Keywords: Adenomatous Polyps; Helicobacter pylori Infection; Immunoglobulins; Neoplasias; Serum.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there was no conflict of interest.

References

    1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008. Int J Cancer . 2010;127(12):2893–2917. - PubMed
    1. Gutman M, Fidler IJ. Biology of human colon cancer metastasis. World J Surg . 1995;19(2):226–234. - PubMed
    1. Rickert RR, Auerbach O, Garfinkel L, Ham- mond EC, Frasca JM. Adenomatous lesions of the large bowel: an autopsy survey. Cancer. 1979;43(5):1847–1857. - PubMed
    1. Monajemmi AR. Cancer. Second ed. Tehran: Azadmhr Publication; 2000.
    1. Azadeh S, Moghimi-Dehkordi B, Fatem SR, Pourhoseingholi MA, Ghiasi S, Zali MR. Colorectal cancer in Iran: an epidemiological study. Asian Pacific J Cancer Prev. 2008;9(1):123–126. - PubMed

LinkOut - more resources