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Review
. 2019 Jan 8:14:1.
doi: 10.1186/s13020-018-0223-8. eCollection 2019.

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Yi-Yao Yang  1 , Feng-Qing Yang  1 , Jian-Li Gao  2
Affiliations
Review

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Yi-Yao Yang et al. Chin Med. .

Abstract

Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes their functions. In this paper, the applications of differential proteomics in exploring the action mechanisms of TCMs on various diseases including cancers, cardiovascular diseases, diabetes, liver diseases, kidney disorders and obesity, etc. were reviewed. Furthermore, differential proteomics in studying of TCMs identification, toxicity, processing and compatibility mechanisms were also included. This review will provide information for the further applications of differential proteomics in TCMs studies.

Keywords: Action mechanisms; Differential proteomics; Identification; Traditional Chinese medicines.

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Figures

Fig. 1
Fig. 1
Schematic diagram of the experimental procedure for differential proteomics in studying of TCMs
Fig. 2
Fig. 2
Chemical structures of main monomers involved in this paper
Fig. 3
Fig. 3
The 2-DE proteome images of control (a) and RC-treated (b) platelets. The differentially expressed protein spots were shown by the arrows Reproduced from ref [19] with permission from the authors
See this image and copyright information in PMC

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