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. 2019 Feb;47(2):255-262.
doi: 10.1007/s11239-018-1778-z.

Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population

Jung Oh Kim  1 , Hyun Woo Kim  1 , Hui Jeong An  1 , Ok Joon Kim  2 , Jisu Oh  3 , So Young Chong  3 , Won-Il Choi  4 , Doyeun Oh  3 , Nam Keun Kim  5
Affiliations

Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population

Jung Oh Kim et al. J Thromb Thrombolysis. 2019 Feb.

Abstract

Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.

Keywords: Deep vein thrombosis; MicroRNA; Pulmonary embolism; Single nucleotide polymorphism.

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