Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep;234(9):14445-14459.
doi: 10.1002/jcp.28141. Epub 2019 Jan 13.

Critical limb ischemia: Current and novel therapeutic strategies

Mohammadhossein Hassanshahi  1 , Samira Khabbazi  1 , Yaser Peymanfar  1 , Alireza Hassanshahi  2 , Zahra Hosseini-Khah  3 , Yu-Wen Su  1 , Cory J Xian  1
Affiliations
Review

Critical limb ischemia: Current and novel therapeutic strategies

Mohammadhossein Hassanshahi et al. J Cell Physiol. 2019 Sep.

Abstract

Critical limb ischemia (CLI) is the advanced stage of peripheral artery disease spectrum and is defined by limb pain or impending limb loss because of compromised blood flow to the affected extremity. Current conventional therapies for CLI include amputation, bypass surgery, endovascular therapy, and pharmacological approaches. Although these conventional therapeutic strategies still remain as the mainstay of treatments for CLI, novel and promising therapeutic approaches such as proangiogenic gene/protein therapies and stem cell-based therapies have emerged to overcome, at least partially, the limitations and disadvantages of current conventional therapeutic approaches. Such novel CLI treatment options may become even more effective when other complementary approaches such as utilizing proper bioscaffolds are used to increase the survival and engraftment of delivered genes and stem cells. Therefore, herein, we address the benefits and disadvantages of current therapeutic strategies for CLI treatment and summarize the novel and promising therapeutic approaches for CLI treatment. Our analyses also suggest that these novel CLI therapeutic strategies show considerable advantages to be used when current conventional methods have failed for CLI treatment.

Keywords: angiogenesis; bio-scaffolds; critical limb ischemia; stem cell therapy.

PubMed Disclaimer

References

REFERENCES
    1. Abbruzzese, T. A., Havens, J., Belkin, M., Donaldson, M. C., Whittemore, A. D., Liao, J. K., & Conte, M. S. (2004). Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts. Journal of Vascular Surgery, 39(6), 1178-1185.
    1. Abu Dabrh, A. M., Steffen, M. W., Undavalli, C., Asi, N., Wang, Z., Elamin, M. B., … Murad, M. H. (2015). The natural history of untreated severe or critical limb ischemia. Journal of Vascular Surgery, 62(6), 1642-1651.
    1. Acosta, L., Hmadcha, A., Escacena, N., Perez-Camacho, I., de la Cuesta, A., Ruiz-Salmeron, R., … Soria, B. (2013). Adipose mesenchymal stromal cells isolated from type 2 diabetic patients display reduced fibrinolytic activity. Diabetes, 62(12), 4266-4269.
    1. Adam, D. J., Beard, J. D., Cleveland, T., Bell, J., Bradbury, A. W., Forbes, J. F., … Storkey, H. (2005). Bypass versus angioplasty in severe ischaemia of the leg (BASIL): Multicentre, randomised controlled trial. Lancet, 366(9501), 1925-1934.
    1. Aiello, F. A., Khan, A. A., Meltzer, A. J., Gallagher, K. A., McKinsey, J. F., & Schneider, D. B. (2012). Statin therapy is associated with superior clinical outcomes after endovascular treatment of critical limb ischemia. Journal of Vascular Surgery, 55(2), 371-379.

LinkOut - more resources