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Comment
. 2019 Feb 1;129(2):503-505.
doi: 10.1172/JCI125985. Epub 2019 Jan 14.

Colorectal cancer: the APC-lncRNA link

Pat J Morin
Comment

Colorectal cancer: the APC-lncRNA link

Pat J Morin. J Clin Invest. .

Abstract

The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in the regulation of cell proliferation and survival through its ability to regulate canonical Wnt signaling. In this issue of the JCI, Wang et al. provide an intriguing new mechanism for APC function involving the regulation of a novel long noncoding RNA (lncRNA), leading to changes in exosome production. APC signaling via this novel pathway can regulate cell proliferation and invasion as well as angiogenesis. In addition to enhancing our understanding of APC function, this new mechanism is of particular clinical significance, as it may provide additional targets for the treatment of APC-mutated cancers.

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Conflict of interest statement

Conflict of interest: The author has declared that no conflict of interest exists.

Figures

Figure 1
Figure 1. Summary of pathways and functions attributed to APC.
See this image and copyright information in PMC

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References

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