doi: 10.1084/jem.147.4.1291.
Cytotoxic T cells recognize male antigen and H-2 as distinct entities
- PMID: 306412
- PMCID: PMC2184235
- DOI: 10.1084/jem.147.4.1291
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Cytotoxic T cells recognize male antigen and H-2 as distinct entities
J Exp Med.
.
Abstract
XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice depleted of alloreactive T cells, however, cannot be sensitized to lyse allogeneic XY targets. The results imply that T cells recognize the Y-antigen and H-2 as distinct entities, and that in chimeras, they acquire the potential to react against allogeneic XY cells.
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