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. 2019 Jan 12;20(2):288.
doi: 10.3390/ijms20020288.

Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers

Roos E Marck  1   2   3 , Kim L M Gardien  4   5 , Marcel Vlig  6 , Roelf S Breederveld  7   8 , Esther Middelkoop  9   10   11
Affiliations

Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers

Roos E Marck et al. Int J Mol Sci. .

Abstract

Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. In this study, growth factor quantification measurements of PRP from burn patients and gender- and age-matched controls were performed. The PRP of burn patients showed levels of growth factors comparable to those of the PRP of healthy volunteers. Considerable intra-individual variation in growth factor content was found. However, a correlation was found between the platelet count of the PRP and most of the growth factors measured.

Keywords: burns; growth factors; platelet rich plasma; platelets; quantification.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Platelet count in whole blood versus platelet count platelet rich plasma (PRP), in patient group and in volunteer group; the platelet concentration factor is depicted underneath the arrow; under patient group the post- burn day is shown.
Figure 2
Figure 2
Growth factor quantification per platelet count in platelet rich plasma (PRP) for transforming growth factor β (TGFβ1).
Figure 3
Figure 3
Growth factor quantification per platelet count in platelet rich plasma (PRP) for platelet derived growth factor (PDGF) AA.
Figure 4
Figure 4
Growth factor quantification per platelet count in platelet rich plasma (PRP) for vascular endothelial growth factor (VEGF).
See this image and copyright information in PMC

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