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Comment
. 2019 Apr 1;25(7):2027-2029.
doi: 10.1158/1078-0432.CCR-18-3877. Epub 2019 Jan 14.

No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity

Yasmin G Hernandez-Barco  1   2 , Nabeel Bardeesy  1 , David T Ting  3
Affiliations
Comment

No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity

Yasmin G Hernandez-Barco et al. Clin Cancer Res. .

Abstract

Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic cancer precursor lesion with established genetic features, but the cellular ecosystem of these tumors remains to be fully characterized. This study utilizes single-cell RNA sequencing to describe the dynamic landscape of epithelial, immune, and stromal cells during IPMN progression to invasive cancer.See related article by Bernard et al., p. 2194.

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Conflict of interest statement

Conflicts of Interest and Disclosures:

Y. G. H-B and N.B. have no conflicts to disclose.

D.T.T. receives sponsored research support from ACD-Biotechne. D.T.T. has performed consulting for Millipore-Sigma, Ventana-Roche, and Merrimack Pharmaceuticals. D.T.T. is a founder and has equity in PanTher Therapeutics. None of the above relationships is believed to be in conflict with this work.

Figures

Figure 1:
Figure 1:
Diagram of single cells found in low-grade dysplasia IPMN, high-grade dysplasia IPMN and PDAC. Activated CD4+ and CD8+ T cells, cDC2 dendritic cells, and rare CD19+ CD20+ B cells are found in LGD-IPMN and HGD-IPMN, with transition to Tregs and MDSCs enriched in PDAC. Myofibroblasts (myCAFs) are found in LGD-IPMN and HGD-IPMN with transition to inflammatory CAFs (iCAFs) cells during malignant progression.
See this image and copyright information in PMC

Comment on

References

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