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Comment
. 2019 Jan 22;116(4):1081-1083.
doi: 10.1073/pnas.1819472116. Epub 2019 Jan 14.

Molecular origins and outcomes of status and stress in primates

Caitlin N Friesen  1 , Hans A Hofmann  2   3   4
Affiliations
Comment

Molecular origins and outcomes of status and stress in primates

Caitlin N Friesen et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Effects of social rank on blood cell gene expression and regulation vary by species and treatment according to two new studies in PNAS (9, 10). (A) The Toll-like receptor 4 (TLR4) is activated by bacterial LPS, which induces a MyD88-dependent proinflammatory pathway and a Toll/IL-1 receptor domain-containing adaptor-inducing IFN-β (TRIF)-dependent antiviral pathway. Also shown is the GC hormone-induced GC receptor (GR) pathway to highlight interactions across LPS and GC treatment. Social rank-mediated effects on gene expression in response to LPS are represented for female macaques and male baboons, while rank-mediated effects on chromatin accessibility are represented for female macaques. (B) Overview of the relative scale of rank-mediated differences in gene expression and chromatin accessibility in female macaques in response to LPS and GC (Dex) treatment. IRF, interferon regulatory factor.
See this image and copyright information in PMC

Comment on

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