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Review
. 2018 Dec 27:14:53-63.
doi: 10.2147/CIA.S190713. eCollection 2019.

Influence of diabetes mellitus on anterior segment of the eye

Sang Beom Han  1 , Hee Kyung Yang  2 , Joon Young Hyon  2
Affiliations
Review

Influence of diabetes mellitus on anterior segment of the eye

Sang Beom Han et al. Clin Interv Aging. .

Abstract

Diabetes mellitus (DM) has been emerging as one of the most serious health problems worldwide. Ocular complications of DM are currently one of the major causes of blindness in developed countries, among which diabetic retinopathy is relatively well studied and understood. However, although ocular surface complications of DM are common, diabetic complications of anterior segment of the eye, such as, cornea, conjunctiva, and lacrimal glands, are often overlooked. DM is associated with progressive damage to corneal nerves and epithelial cells, which increases the risk of anterior segment disorders including dry eye disease, corneal erosion, persistent epithelial defects, and even sight-threatening corneal ulcer. In this review, the authors will discuss the association of DM with disorders of anterior segment of the eye. Studies indicating the value of corneal nerve assessment as a sensitive, noninvasive, and repeatable biomarker for diabetic neuropathy will also be introduced. In addition, treatment modalities of anterior segment disorders associated with DM is discussed. The studies introduced in this review suggest that early and periodic screening of the anterior segment of the eye, as well as the retina, is important for the optimal treatment of DM.

Keywords: anterior segment disease; corneal neuropathy; diabetes mellitus; dry eye disease; keratopathy; ocular surface disease.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Graphical overview of this review.
Figure 2
Figure 2
Pathogenesis of diabetic corneal neuropathy.
See this image and copyright information in PMC

References

    1. Alberti KG, Zimmet PZ, Definition ZPZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–553. - PubMed
    1. Shih KC, Lam KS, Tong L. A systematic review on the impact of diabetes mellitus on the ocular surface. Nutr Diabetes. 2017;7(3):e251. - PMC - PubMed
    1. Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M. The impact of diabetes on corneal nerve morphology and ocular surface integrity. Ocul Surf. 2018;16(1):45–57. - PubMed
    1. Noh J. The diabetes epidemic in Korea. Endocrinol Metab (Seoul) 2016;31(3):349–353. - PMC - PubMed
    1. Abdelkader H, Patel DV, McGhee CNJ, Alany RG. New therapeutic approaches in the treatment of diabetic keratopathy: a review. Clin Exp Ophthalmol. 2011;39(3):259–270. - PubMed