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Case Reports
. 2018 Dec 19:5:e102.
doi: 10.14309/crj.2018.102. eCollection 2018.

Ganciclovir-Resistant CMV Colitis in a Donor-Seronegative/Recipient-Seronegative Liver Transplant Patient

Samuel O Igbinedion  1 , Krunal Patel  2 , Hrishikesh Samant  2 , Gregory P Wellman  3
Affiliations
Case Reports

Ganciclovir-Resistant CMV Colitis in a Donor-Seronegative/Recipient-Seronegative Liver Transplant Patient

Samuel O Igbinedion et al. ACG Case Rep J. .

Abstract

Cytomegalovirus (CMV) disease in liver transplant patients with donor-seronegative and recipient-seronegative (D-/R-) status is a rarity. Ganciclovir-resistant CMV disease in this population has not been reported in the literature. We present a 62-year-old man who underwent orthotopic liver transplant from a cadaveric donor. The patient's status was CMV D-/R-, and he had completed 90 days of valganciclovir therapy for CMV prophylaxis, yet he developed CMV disease. We highlight the danger of the liberal use of CMV prophylaxis in this subset of the liver transplant population. To our knowledge, this is the first report of ganciclovir-resistant (GanR) CMV disease in a liver transplant patient with CMV D-/R- status.

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Figures

Figure 1
Figure 1
Flexible sigmoidoscopy revealing erythematous mucosa in the sigmoid colon and no evident ulcers. The sigmoid mucosal view is limited by poor preparation prior to the procedure.
Figure 2
Figure 2
Immunohistochemical stain demonstrating positive cytomegalovirus immunoreactivity (arrows).
See this image and copyright information in PMC

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