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Review
. 2019 May;37(2):175-185.
doi: 10.5534/wjmh.180069. Epub 2019 Jan 10.

Traditional Chinese Medicine as a Remedy for Male Infertility: A Review

Shao Hu Zhou  1 , Yu Fei Deng  2 , Zhi Wei Weng  3 , Hao Wei Weng  2 , Zhi Dan Liu  2
Affiliations
Review

Traditional Chinese Medicine as a Remedy for Male Infertility: A Review

Shao Hu Zhou et al. World J Mens Health. 2019 May.

Abstract

Male infertility (MI) is a complex multifactorial disease, and idiopathic infertility accounts for 30% of cases of MI. At present, the evidence for the effectiveness of empirical drugs is limited, and in vitro fertilization is costly and may increase the risk of birth defects and childhood cancers. Therefore, affected individuals may feel obliged to pursue natural remedies. Traditional Chinese medicine (TCM) may represent a useful option for infertile men. It has been demonstrated that TCM can regulate the hypothalamic-pituitary-testicular axis and boost the function of Sertoli cells and Leydig cells. TCM can also alleviate inflammation, prevent oxidative stress, reduce the DNA fragmentation index, and modulate the proliferation and apoptosis of germ cells. Furthermore, TCM can supply trace elements and vitamins, ameliorate the microcirculation of the testis, decrease the levels of serum anti-sperm antibody, and modify epigenetic markers. However, the evidence in favor of TCM is not compelling, which has hindered the development of TCM. This review attempts to elucidate the underlying therapeutic mechanisms of TCM. We also explore the advantages of TCM, differences between TCM and Western medicine, and problems in existing studies. Subsequently, we propose solutions to these problems and present perspectives for the future development of TCM.

Keywords: Infertility, male; Medicine, Chinese traditional; Therapeutics.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. Potential therapeutic mechanisms of TCM. TCM: Traditional Chinese medicine, H-P-T: hypothalamic-pituitary-testicular, SCs: Sertoli cells, LCs: Leydig cells, ROS: reactive oxygen species, AsAb: anti-sperm antibody.
See this image and copyright information in PMC

References

    1. Rowe PJ. WHO manual for the standardized investigation, diagnosis and management of the infertile male. 5th ed. Cambridge: Cambridge University Press; 2000. pp. 1–5.
    1. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, et al. European Association of Urology guidelines on male infertility: the 2012 update. Eur Urol. 2012;62:324–332. - PubMed
    1. Garg H, Kumar R. Empirical drug therapy for idiopathic male infertility: what is the new evidence? Urology. 2015;86:1065–1075. - PubMed
    1. Cen YH, Zhao FL, Fan R, He GZ. Research progress in the reproductive-related kidney deficiency and kidney tonifying Chinese medicine mechanism. Med Recapitulate. 2014;20:2226–2228.
    1. Qian FL, Zeng FH, Feng WQ. Effects of Chinese herbal preparation for invigorating kidney on function of hypothalamicpituitary-gonad axis in rats. Chin J Sports Med. 2005;24:571–575.