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. 2019 Feb;37(2):347-355.
doi: 10.1097/HJH.0000000000001886.

Stiffening and ventricular-arterial interaction in the ascending aorta using MRI: ageing effects in healthy humans

Ye Li  1   2 , Stacey S Hickson  3 , Carmel M McEniery  3 , Ian B Wilkinson  3 , Ashraf W Khir  2
Affiliations

Stiffening and ventricular-arterial interaction in the ascending aorta using MRI: ageing effects in healthy humans

Ye Li et al. J Hypertens. 2019 Feb.

Abstract

Objectives: The aim of this study was to investigate the effect of age and sex on nPWV and ndI in the ascending aorta of healthy humans.

Background: Local pulse wave velocity (nPWV) and wave intensity (ndI) in the human ascending aorta have not been studied adequately, because of the need for invasive pressure measurements. However, a recently developed technique made the noninvasive determination of nPWV and ndI possible using measurements of flow velocity and arterial diameter.

Methods: Diameter and flow velocity were measured at the level of the ascending aorta in 144 healthy participants (aged 20-77 years, 66 men), using MRI. nPWV, ndI parameters; forward (FCW); backward (BCW) compression waves, forward decompression wave (FDW), local aortic distensibility (nDs) and reflection index (nRI) were calculated.

Results: nPWV increased significantly with age from 4.7 ± 0.3 m/s for those 20-30 years to 6.4 ± 0.2 m/s for those 70-80 years (P < 0.001) and did not differ between sexes. nDs decreased with age (5.3 ± 0.5 vs. 2.6 ± 0.2 10 1/Pa, P < 0.001) and nRI increased with age (0.17 ± 0.03 vs. 0.39 ± 0.06, P < 0.01) for those 20-30 and 70-80 years, respectively. FCW, BCW and FDW decreased significantly with age by 86.3, 71.3 and 74.2%, respectively (P < 0.001), all compared to the lowest age-band.

Conclusion: In healthy humans, ageing results in stiffer ascending aorta, with increase in nPWV and decrease in nDs. A decrease in FCW and FDW indicates decline in left ventricular early and late systolic functions with age in healthy humans with no differences between sexes. nRI is more sensitive than BCW in establishing the effects of ageing on reflected waves measured in the ascending aorta.

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Figures

FIGURE 1
FIGURE 1
Determination of pulse wave velocity, and the separation of waves. Diameter (A) and flow velocity (B) measured in the ascending aorta of a typical healthy subject (male, age 41), using MRI. In early systole, the relationship between the velocity and logarithm of diameter is linear, as shown in the initial part of the lnDU-loop (C) and the slope (highlighted in dark grey dash line) of which indicates local PWV of 5.1 m/s as calculated using equation (1). Using knowledge of PWV with dU and dlnD data, the net, forward (dashed) and backward (dotted) wave intensities were calculated using equations (3) and finally plotted against time (F). PWV, pulse wave velocity.
FIGURE 2
FIGURE 2
Relationship between age and ascending aorta pulse wave velocity for all participants, linear data fitting (R = 0.40, P < 0.001).
FIGURE 3
FIGURE 3
Local pulse wave velocity (a), diameter (b), flow velocity (c), forward compression wave; backward compression wave (d), backward compression wave (e) and forward decompression wave (f) are shown as a function of age with sex. BCW, backward compression wave; FCW, forward compression wave; FDW, forward decompression wave.
FIGURE 4
FIGURE 4
Reflection index (a) and distensibility (b) are shown as a function of age and sex. nRI increased but distensibility decreased with age for both sexes.nRI, reflection index.
See this image and copyright information in PMC

Comment in

References

    1. Bramwell JC, Hill AV. The velocity of the pulse wave in man. Proc R Soc B Biol Sci 1922; 93:298–306.
    1. Blacher J, Asmar R, Djane S, London GM, Safar ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999; 33:1111–1117. - PubMed
    1. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37:1236–1241. - PubMed
    1. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, et al. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34:1203–1206. - PubMed
    1. Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 2014; 63:636–646. - PMC - PubMed