Hijacking EMT: Better Fat Than Dead
- PMID: 30645968
- DOI: 10.1016/j.ccell.2018.12.007
Hijacking EMT: Better Fat Than Dead
Abstract
Potential for cancers to form metastases requires cell dissemination utilizing epithelial-to-mesenchymal transition (EMT) program. In this issue of Cancer Cell, Ishay-Ronen et al. show that plasticity intrinsic to the EMT program can be exploited to divert cancer cells into becoming post-mitotic adipocytes, thus preventing formation of metastases.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis.Cancer Cell. 2019 Jan 14;35(1):17-32.e6. doi: 10.1016/j.ccell.2018.12.002. Cancer Cell. 2019. PMID: 30645973
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