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Comment
. 2019 Jan 14;35(1):3-5.
doi: 10.1016/j.ccell.2018.12.006.

Tumor Extracellular Vesicles Impede Interferon Alert Responses

Candia M Kenific  1 , Gang Wang  1 , David Lyden  2
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Comment

Tumor Extracellular Vesicles Impede Interferon Alert Responses

Candia M Kenific et al. Cancer Cell. .
Free article

Abstract

Tumor-derived extracellular vesicles promote metastasis by inducing functional changes in cells at pre-metastatic sites conducive for tumor cell colonization. In this issue of Cancer Cell, Ortiz and colleagues show that type I interferon regulates extracellular vesicle uptake and that modulating this pathway holds promise for treating metastasis.

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  • An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
    Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY. Ortiz A, et al. Cancer Cell. 2019 Jan 14;35(1):33-45.e6. doi: 10.1016/j.ccell.2018.12.001. Cancer Cell. 2019. PMID: 30645975 Free PMC article.

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