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Comment
. 2019 Jan 14;35(1):5-7.
doi: 10.1016/j.ccell.2018.12.004.

The Deadly Bite of STAT3

Hagen Schwenzer  1 , Ariberto Fassati  2
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The Deadly Bite of STAT3

Hagen Schwenzer et al. Cancer Cell. .
Free article

Abstract

The Tasmanian devils' facial tumor disease (DFTD) is a transmissible cancer that spreads by biting and threatens extinction of this marsupial. In this issue of Cancer Cell, Kosack et al. describe how overexpression of ERBB and uncontrolled activation of STAT3 drive DFTD growth and immune evasion.

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  • The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.
    Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P, Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H, de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV, Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A. Kosack L, et al. Cancer Cell. 2019 Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018. Cancer Cell. 2019. PMID: 30645971 Free PMC article.

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