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. 2018 Dec 7;1(8):e186371.
doi: 10.1001/jamanetworkopen.2018.6371.

Prevalence of Hepatitis C Virus Infection in US States and the District of Columbia, 2013 to 2016

Eli S Rosenberg  1 , Elizabeth M Rosenthal  1 , Eric W Hall  2 , Laurie Barker  3 , Megan G Hofmeister  3 , Patrick S Sullivan  2 , Patricia Dietz  4 , Jonathan Mermin  4 , A Blythe Ryerson  3
Affiliations

Prevalence of Hepatitis C Virus Infection in US States and the District of Columbia, 2013 to 2016

Eli S Rosenberg et al. JAMA Netw Open. .

Abstract

Importance: Infection with hepatitis C virus (HCV) is a major cause of morbidity and mortality in the United States, and incidence has increased rapidly in recent years, likely owing to increased injection drug use. Current estimates of prevalence at the state level are needed to guide prevention and care efforts but are not available through existing disease surveillance systems.

Objective: To estimate the prevalence of current HCV infection among adults in each US state and the District of Columbia during the years 2013 to 2016.

Design, setting, and participants: This survey study used a statistical model to allocate nationally representative HCV prevalence from the National Health and Nutrition Examination Survey (NHANES) according to the spatial demographics and distributions of HCV mortality and narcotic overdose mortality in all National Vital Statistics System death records from 1999 to 2016. Additional literature review and analyses estimated state-level HCV infections among populations not included in the National Health and Nutrition Examination Survey sampling frame.

Exposures: State, accounting for birth cohort, biological sex, race/ethnicity, federal poverty level, and year.

Main outcomes and measures: State-level prevalence estimates of current HCV RNA.

Results: In this study, the estimated national prevalence of HCV from 2013 to 2016 was 0.84% (95% CI, 0.75%-0.96%) among adults in the noninstitutionalized US population represented in the NHANES sampling frame, corresponding to 2 035 100 (95% CI, 1 803 600-2 318 000) persons with current infection; accounting for populations not included in NHANES, there were 231 600 additional persons with HCV, adjusting prevalence to 0.93%. Nine states contained 51.9% of all persons living with HCV infection (California [318 900], Texas [202 500], Florida [151 000], New York [116 000], Pennsylvania [93 900], Ohio [89 600], Michigan [69 100], Tennessee [69 100], and North Carolina [66 400]); 5 of these states were in Appalachia. Jurisdiction-level median (range) HCV RNA prevalence was 0.88% (0.45%-2.34%). Of 13 states in the western United States, 10 were above this median. Three of 10 states with the highest HCV prevalence were in Appalachia.

Conclusions and relevance: Using extensive national survey and vital statistics data from an 18-year period, this study found higher prevalence of HCV in the West and Appalachian states for 2013 to 2016 compared with other areas. These estimates can guide state prevention and treatment efforts.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Rosenberg reported personal fees from Cengage Learning and from Statistics.com outside the submitted work. Mr Hall reported grants from the Center for AIDS Research at Emory University during the conduct of the study. Ms Barker reported employment with the Centers for Disease Control and Prevention (CDC) Division of Viral Hepatitis, which funds state and local governments and community health centers to prevent and control hepatitis C virus infections, and strengthen surveillance for viral hepatitis B and C. Dr Sullivan reported grants from the CDC during the conduct of the study and personal fees from the CDC, grants and personal fees from the National Institutes of Health, and grants from Gilead Sciences outside the submitted work. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Estimated Hepatitis C Virus (HCV) RNA Prevalence and Total Persons With HCV RNA, Indicating Current Infection, United States and District of Columbia, 2013 to 2016
Prevalence of HCV (A) and total number of persons with HCV (B) in the full US adult population defined by noninstitutionalized adults included in the National Health and Nutrition Examination Survey sampling frame and additional populations not in the sampling frame (those incarcerated, in nursing homes, and experiencing homelessness).
Figure 2.
Figure 2.. Hepatitis C Virus (HCV) RNA Prevalence, Accounting for the Distribution of Both HCV and Narcotic Overdose Deaths or HCV Deaths Only, by US State and Census Region, 2013 to 2016
Prevalence in the US adult population defined by noninstitutionalized adults included in the National Health and Nutrition Examination Survey sampling frame. Error bars represent 95% confidence intervals. ICD-10 indicates International Classification of Diseases, Tenth Revision.
See this image and copyright information in PMC

References

    1. Ditah I, Ditah F, Devaki P, et al. . The changing epidemiology of hepatitis C virus infection in the United States: National Health and Nutrition Examination Survey 2001 through 2010. J Hepatol. 2014;60(4):-. doi:10.1016/j.jhep.2013.11.014 - DOI - PubMed
    1. Liang TJ, Rehermann B, Seeff LB, Hoofnagle JH. Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann Intern Med. 2000;132(4):296-305. doi:10.7326/0003-4819-132-4-200002150-00008 - DOI - PubMed
    1. Thomas DL, Seeff LB. Natural history of hepatitis C. Clin Liver Dis. 2005;9(3):383-398, vi. doi:10.1016/j.cld.2005.05.003 - DOI - PubMed
    1. Micallef JM, Kaldor JM, Dore GJ. Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat. 2006;13(1):34-41. doi:10.1111/j.1365-2893.2005.00651.x - DOI - PubMed
    1. Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014;61(1)(suppl):S58-S68. doi:10.1016/j.jhep.2014.07.012 - DOI - PubMed

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