Intravitreal ranibizumab or conbercept for retinal arterial macroaneurysm: a case series
- PMID: 30646868
- PMCID: PMC6334469
- DOI: 10.1186/s12886-019-1035-z
Intravitreal ranibizumab or conbercept for retinal arterial macroaneurysm: a case series
Abstract
Background: There is no consensus for the standard treatment of retinal arterial macroaneurysm (RAM). Intravitreal anti-vascular endothelium growth factor (anti-VEGF) is an alternative treatment option for RAM. The purpose of this study is to describe the clinical efficacy of intravitreal ranibizumab or intravitreal conbercept for retinal arterial macroaneurysm.
Case presentation: Three cases that presented with symptomatic RAM were treated with intravitreal anti-VEGF agents. Two eyes received two intravitreal ranibizumab injections with a time interval of one month and completed a one-year follow-up, while one eye only received one intravitreal conbercept injection and was followed up for six months. Both the retinal thickness and the visual acuity were significantly improved at the final clinic visit. The macular hemorrhage and edema were resolved. There were no ocular or systemic side effects.
Conclusions: Intravitreal ranibizumab or conbercept might be used as a therapeutic option for symptomatic retinal arterial macroaneurysm patients. Anti-VEGF therapy should be further investigated in a larger series with longer follow-up for this disease profile.
Keywords: Conbercept; Ranibizumab; Retinal arterial macroaneurysm.
Conflict of interest statement
Ethics approval and consent to participate
The study was adhered to the tenets of the Declaration of Helsinki. Written informed consents were obtained from the patients before the surgery. The study conforms to the ethical guidelines of the Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University (Shanghai, China).
Consent for publication
Written informed consents for publication of the clinical details were obtained from the patients.
Competing interests
The authors declare that they have no competing interests.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Figures





References
-
- Robertson DM. Macroaneurysms of the retinal arteries. Trans Am Acad Ophthalmol Otolaryngol. 1973;77(1):55–67. - PubMed
-
- Contreras JE, Mittra RB, Mieler WF, Pollack JS. Retina arterial macroaneurysms. In: Yanoff M, Duker JS, editors. Ophthalmology. 2. Philadelphia: Mosby Elsevier; 2004. pp. 912–917.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical