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Comment
. 2019 Feb 4;218(2):385-386.
doi: 10.1083/jcb.201811170. Epub 2019 Jan 15.

A mosaic of old and young nucleoporins

Takeshi Shimi  1 , Hiroshi Kimura  2
Affiliations
Comment

A mosaic of old and young nucleoporins

Takeshi Shimi et al. J Cell Biol. .

Abstract

Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in quiescent cells.

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Figures

Figure 1.
Figure 1.
Mechanisms of NPC maintenance. Whole-pore Nup exchange in quiescent cells and piecemeal replacement of subcomplex components in terminally differentiated cells. Rapidly exchanging Nups in any cell states are shown in gray.
See this image and copyright information in PMC

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