Dendritic cells mature to resist lamin degradation and herpes virus release

Abstract

Herpes simplex viruses bud into the nuclear membrane of infected cells. Turan et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201801151) demonstrate that mature dendritic cells control the peripheral location of lysosomes, reducing autophagic degradation of lamins and inhibiting viral release.

Figure 1.

Lysosome positioning regulates herpesvirus egress from the nucleus and viral release in dendritic cells. Immature dendritic cells (left) have low levels of expression of the KIF1B and KIF2A kinesins. Lysosomes accumulate in the center of the cell. Autophagy induction following herpesvirus infection leads to efficient degradation of the nuclear intermediate filaments lamins and efficient viral egress. In mature dendritic cells (right), the high kinesins activity maintains a peripheral location of the lysosomes, which prevents efficient degradation of lamins and therefore limits viral egress.