Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Nov-Dec;28(6):462-464.
doi: 10.4103/ijn.IJN_235_17.

Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy

S Nayak  1 , A Kataria  1 , M K Sharma  2 , A Rastogi  3 , E Gupta  4 , A Singh  1 , S C Tiwari  1
Affiliations
Case Reports

Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy

S Nayak et al. Indian J Nephrol. 2018 Nov-Dec.

Abstract

Hepatitis C virus (HCV) infection has been shown to affect kidneys with various histopathological pattern on the kidney biopsy. These commonly include a membranoproliferative glomerulonephritis (MPGN) pattern with mixed cryoglobulinemia (CG), thrombotic microangiopathy, membranous nephropathy, and vasculitis affecting medium and small vessels of the kidneys causing polyarteritis nodosa. It has been rarely associated with MPGN without detectable CG. We present one such patient who presented to us with HCV-associated MPGN without detectable CG, who recovered completely with directly acting antiviral therapy without any immunosuppression.

Keywords: Cryoglobulinemia; hepatitis C; membranoproliferative glomerulonephritis.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Erythematous maculopapular rash on the extensor surface of lower extremities
Figure 2
Figure 2
Light microscopy (Hematoxylin and Eosin) showing enlarged hypercellular glomerulus with capillary wall thickening, double contouring and increased mesangial matrix and cellularity
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Johnson RJ, Willson R, Yamabe H, Couser W, Alpers CE, Wener MH, et al. Renal manifestations of hepatitis C virus infection. Kidney Int. 1994;46:1255–63. - PubMed
    1. Sumida K, Ubara Y, Hoshino J, Suwabe T, Nakanishi S, Hiramatsu R, et al. Hepatitis C virus-related kidney disease: Various histological patterns. Clin Nephrol. 2010;74:446–56. - PubMed
    1. Sood A, Sarin SK, Midha V, Hissar S, Sood N, Bansal P, et al. Prevalence of hepatitis C virus in a selected geographical area of Northern India: A population based survey. Indian J Gastroenterol. 2012;31:232–6. - PubMed
    1. Markowitz GS, Cheng JT, Colvin RB, Trebbin WM, D’Agati VD. Hepatitis C viral infection is associated with fibrillary glomerulonephritis and immunotactoid glomerulopathy. J Am Soc Nephrol. 1998;9:2244–52. - PubMed
    1. Arase Y, Ikeda K, Murashima N, Chayama K, Tsubota A, Koida I, et al. Glomerulonephritis in autopsy cases with hepatitis C virus infection. Intern Med. 1998;37:836–40. - PubMed

Publication types