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Case Reports
. 2018 Nov-Dec;28(6):462-464.
doi: 10.4103/ijn.IJN_235_17.

Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy

S Nayak  1 , A Kataria  1 , M K Sharma  2 , A Rastogi  3 , E Gupta  4 , A Singh  1 , S C Tiwari  1
Affiliations
Case Reports

Hepatitis C Virus-associated Membranoproliferative Glomerulonephritis Treated with Directly Acting Antiviral Therapy

S Nayak et al. Indian J Nephrol. 2018 Nov-Dec.

Abstract

Hepatitis C virus (HCV) infection has been shown to affect kidneys with various histopathological pattern on the kidney biopsy. These commonly include a membranoproliferative glomerulonephritis (MPGN) pattern with mixed cryoglobulinemia (CG), thrombotic microangiopathy, membranous nephropathy, and vasculitis affecting medium and small vessels of the kidneys causing polyarteritis nodosa. It has been rarely associated with MPGN without detectable CG. We present one such patient who presented to us with HCV-associated MPGN without detectable CG, who recovered completely with directly acting antiviral therapy without any immunosuppression.

Keywords: Cryoglobulinemia; hepatitis C; membranoproliferative glomerulonephritis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Erythematous maculopapular rash on the extensor surface of lower extremities
Figure 2
Figure 2
Light microscopy (Hematoxylin and Eosin) showing enlarged hypercellular glomerulus with capillary wall thickening, double contouring and increased mesangial matrix and cellularity
See this image and copyright information in PMC

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