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Case Reports
. 2018 Nov-Dec;28(6):472-476.
doi: 10.4103/ijn.IJN_76_17.

Crystalline Nephropathy in Renal Transplant: A Series of 4 Cases

K Mnif  1 , S Yaich  1 , M Mars  1 , K Kammoun  1 , F Fendri  1 , K Charfeddine  1 , F Jarraya  1 , T Boudawara  2 , J Hachicha  1
Affiliations
Case Reports

Crystalline Nephropathy in Renal Transplant: A Series of 4 Cases

K Mnif et al. Indian J Nephrol. 2018 Nov-Dec.

Abstract

Crystals are particles of endogenous inorganic or organic composition that can trigger kidney injury when deposited or formed inside the kidney. The most common forms of crystalline nephropathies (CNs) are nephrocalcinosis and oxalate nephropathy. The causes of early allograft dysfunction are changing constantly, and recently calcium oxalate (CaOx) crystal deposition has been added to this list. CaOx deposition in renal allograft is important and probably under-recognized cause of delayed graft function that requires adequate awareness with early intervention to improve the allograft outcome. Here, we describe four cases of irreversible renal graft injury due to CNs.

Keywords: Crystalline nephropathy; hyperoxaluria; renal allograft dysfunction.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Proximal tubules with diffuse degenerative changes typical of acute necrosis and tubular calcium oxalate crystals (H and E, ×200)
Figure 2
Figure 2
Tubular calcium oxalate deposits appear birefringent under polarized light (H and E, ×200)
Figure 3
Figure 3
Calcium oxalate crystal deposition in the renal tubules under polarized light microscopy
See this image and copyright information in PMC

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