Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec;15(2):423-429.
doi: 10.1016/j.jgeb.2017.05.002. Epub 2017 Jun 9.

Serum apelin levels and metabolic risk markers in obese women

Moushira Zaki  1 , Sanaa Kamal  1 , Wafaa Ezzat  2 , Naglaa Hassan  1 , Walaa Yousef  1 , Hanaa Ryad  1 , Ramy Mohamed  1 , Eman Youness  3 , Walaa Basha  1 , Yasser Elhosary  2
Affiliations

Serum apelin levels and metabolic risk markers in obese women

Moushira Zaki et al. J Genet Eng Biotechnol. 2017 Dec.

Abstract

Background: Adipose tissue hormones, Adipokines, play an important role in obesity-associated complications. Apelin has recently been added to the family of adipokines. The aim of this study was to evaluate the relationship between serum apelin levels and metabolic abnormal parameters in Egyptian obese women.

Materials and methods: The study included 400 unrelated women; they were 200 obese women and 200 non- obese matched healthy women. All participants underwent clinical, anthropometric and biochemical examinations. Insulin resistance (IR) was determined by the homeostasis model assessment of insulin resistance (HOMA-IR). Serum apelin levels and obesity biomarkers were measured using enzyme-linked immunoassay (ELISA) kits. Fat mass was measured by Tanita Body Composition Analyzer.

Results: Obese women showed significant higher levels of serum apelin, leptin, triglycerides, LDL-C, total cholesterol, fasting insulin HOMA-IR and blood pressure levels than controls. Significant positive correlations between apelin and leptin levels with abnormal metabolic markers were noted in obese women.

Conclusion: The present study suggests the significant role that might be mediated by apelin for developing abnormal metabolic parameters among Egyptian obese women.

Keywords: HOMA-IR; Obese; Serum apelin; Women.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Correlation between serum leptin levels and WHR in obese women.
Figure 2
Figure 2
Correlation between serum apelin levels and BMI (kg/m2) in obese women.
Figure 3
Figure 3
Correlation between serum apelin levels and sum of skin folds (mm) in obese women.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bennasar-Veny M., Lopez-Gonzalez A.A., Tauler P., Cespedes M.L., Vicente-Herrero T., Yañez A. Body adiposity index and cardiovascular health risk factors in caucasians: a comparison with the body mass index and others. PLoS One. 2013;8(5):e63999. - PMC - PubMed
    1. Jung U.J., Choi M.-S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int. J. Mol. Sci. 2014;15(4):6184–6223. - PMC - PubMed
    1. Sun X., Wu X., Zhou Y., Yu X., Zhang W. Evaluation of apelin and insulin resistance in patients with PCOS and therapeutic effect of drospirenone-ethinylestradiol plus metformin. Med. Sci. Monitor Int. Med. J. Exp. Clin. Res. 2015;21:2547–2552. - PMC - PubMed
    1. AL-Suhaimi A., Shehzad A. Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity. Euro. J. Med. Res. 2013;18:12. - PMC - PubMed
    1. Castan-Laurell I., Dray C., Attané C., Duparc T., Knauf C., Valet P. Apelin, diabetes, and obesity. Endocrine. 2011 Aug;40(1):1–9. - PubMed

LinkOut - more resources