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Case Reports
. 2019 Aug 9;220(6):951-955.
doi: 10.1093/infdis/jiz025.

Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov  1 , Mark Robbins  2 , Jamie Borlang  1 , Jingxin Cao  1 , Todd Hatchette  3   4 , Ashley Stueck  3   4 , Yvon Deschambault  1 , Kyle Murnaghan  5 , Jessy Varga  1 , Lynn Johnston  5
Affiliations
Case Reports

Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

Anton Andonov et al. J Infect Dis. .

Abstract

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

Keywords: Hepeviridae; Western blot; hepatitis E virus; immunocompetent; phylogenetic analysis.

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