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. 2019 Feb 19;21(3):360-369.
doi: 10.1093/neuonc/noy195.

Malignant primary brain and other central nervous system tumors diagnosed in Canada from 2009 to 2013

Emily V Walker  1 , Faith G Davis  1 ; CBTR founding affiliates
Collaborators, Affiliations

Malignant primary brain and other central nervous system tumors diagnosed in Canada from 2009 to 2013

Emily V Walker et al. Neuro Oncol. .

Abstract

Background: We present a national surveillance report on malignant primary brain and other central nervous system (CNS) tumors diagnosed in the Canadian population in 2009-2013.

Methods: Patients were identified through the Canadian Cancer Registry, an administrative dataset that includes cancer incidence data from all provinces/territories in Canada. Tumor types were classified by site and histology using the definitions from the Central Brain Tumor Registry of the United States (CBTRUS). Incidence rates (IRs) and 95% confidence intervals (CIs) were calculated per 100000 person-years (py) and age-standardized to the 2011 Canadian population for comparisons within Canada and to the 2000 United States population for comparisons with the US.

Results: Overall, 12515 malignant brain and other CNS tumors were diagnosed in the Canadian population in 2009-2013 (IR: 8.71/100000 py; 95% CI: 8.56, 8.86); 7085 were among males (IR: 10.06/100000 py; 95% CI: 9.82, 10.29) and 5430 among females (IR: 7.41/100000 py; 95% CI: 7.22, 7.61). Of these, 12115 were classifiable according to histological subgroups defined by CBTRUS. The most common histology was glioblastoma (IR: 4.06/100000 py; 95% CI: 3.95, 4.16). Among those aged 0-19 years, 1130 malignant brain and CNS tumors were diagnosed in 2009-2013 (IR: 3.36/100000 py; 95% CI: 3.16, 3.56). The most common histology among the pediatric population was embryonal tumor (IR: 0.74/100000 py; 95% CI: 0.65, 0.84).

Conclusions: These data represent an initial detailed report on the frequency and distribution of primary malignant brain and other CNS tumors diagnosed in the Canadian population in 2009-2013. The reported distributions of tumor diagnoses by sex and age reflected expected patterns based on the literature from similar populations. A report incorporating data on nonmalignant primary brain tumors is forthcoming.

Keywords: Canadian surveillance report; epidemiology; malignant brain neoplasms; malignant central nervous system neoplasms; neuro-oncology.

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Figures

Fig. 1
Fig. 1
Incidence rates for brain and other CNS tumors by province/territory and age group, 2009–2013, adjusted for the 2011 Canadian census age distribution.
Fig. 2
Fig. 2
Incidence rates for brain and other CNS tumors by Canadian province/territory, US states, and age group, 2009–2013, adjusted for the 2000 US age distribution.
See this image and copyright information in PMC

Comment in

References

    1. Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2017 2017. cancer.ca/Canadian-CancerStatistics-2017-EN.pdf. Accessed May 19, 2018.
    1. Davis F, Nagamuthu C, Ross J, Megyesi J. Current status of brain tumor surveillance in Canada and why it matters. J Registry Manag. 2015;42(4):139–145. - PubMed
    1. Government of Canada SC. Canadian Cancer Registry (CCR) http://www23.statcan.gc.ca/imdb/p2SV.pl?Function=getSurveyandSDDS=3207#a3. Published January 19, 2018. Accessed July 30, 2018.
    1. Ostrom QT, Gittleman H, Xu J, et al. . CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009–2013. Neuro-Oncol. 2016;18(suppl_5):v1–v75. - PMC - PubMed
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